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Tec-Control Chromatography Systems

Overview

For radiopharmaceutical quality control

Tec-Control Chromatography tests the radiochemical purity of specific Tc-99m-labeled radiopharmaceuticals. The accompanying chart shows which strips and solvents are required to perform each individual test. Some solvents must be purchased separately (see Sigma-Aldrich chart) due to hazardous material shipping restrictions.

Detailed instruction manuals are packaged with each strip container, although our Radiopharmaceutical QC Procedure Manual (151-000) explains paper chromatography in greater detail.

References:
Miniaturized Chromatographic Quality-Control Procedures for Tc-99m Radiopharmaceuticals; A. Michael Zimmer and Dan G. Pavel, Journal of Nuclear Medicine, Vol. 18/12, Dec. 1977, pg. 1230.

Technical Parameters Associated with Miniaturized Chromatography Systems; Raimund A. Taukulis, A. Michael Zimmer, Dan G. Pavel and Bhupendra A. Patel, University of Illinois Medical Center, Chicago, Illinois, Journal of Nuclear Medicine Technology, Vol. 7/1.

or radiopharmaceutical quality control

Detailed instruction manuals are packaged with each strip container, although our Radiopharmaceutical QC Procedure Manual (151-000) explains paper chromatography in greater detail.

References:

Miniaturized Chromatographic Quality-Control Procedures for Tc-99m Radiopharmaceuticals; A. Michael Zimmer and Dan G. Pavel, Journal of Nuclear Medicine, Vol. 18/12, Dec. 1977, pg. 1230.

Solvents

RADIOPHARMACEUTICAL	SOLVENT(S) REQUIRED*	STRIPS REQUIRED
Aluminum Breakthru	150-781 10 µg/ml	150-782
Aluminum Breakthru	150-783 5 µg/ml	150-782
Bicisate (Neurolite™)	Ethyl Acetate 99.%	150-130
Diphosphonate	Acetone (HPLC Grade), Distilled H2O	150-001 & 150-005
Disofenin (Hepatolite™)	150-160, Distilled H2O	150-122 & 150-125
DMSA	Acetone (HPLC Grade),	150-025
DTPA	Acetone (HPLC Grade), Distilled H2O	150-001 & 150-005
Exametazine (Ceretec™)	Ethyl Acetate 99.%	150-130
Fluorodeoxyglucose (FDG)	Acetone (HPLC Grade)	150-127
Glucoheptonate	Acetone (HPLC Grade), Distilled H2O	150-001 & 150-005
HDP	Acetone (HPLC Grade), Distilled H2O	150-001 & 150-005
MAA	Acetone (HPLC Grade),	150-001
MAG3 (Mertiatide™)	Acetone, (HPLC Grade), Chloroform 99.8% Tetrahydrofuran 99+%	150-951 & 150-952
MDP	Acetone (HPLC Grade), Distilled H2O	150-001 & 150-005
Mebrofenin (Cholotec™)	150-160, Distilled H2O	150-122 & 150-125
Pyrophosphate	Acetone (HPLC Grade), Distilled H2O	150-001 & 150-005
Sestamibi (Cardiolite™ and Miraluma™)	Ethyl Acetate 99.%	150-991
Sulphur Colloid	Acetone (HPLC Grade)	150-001
Tc-99m (reduced)	Acetone (HPLC Grade),	150-001
Tc-99m Monoclonal Antibodies	0.9% Saline	150-771
Tetrofosmin (Myoview™)	Ethyl Acetate 99.%	150-971
In-111 Octreotide (Octreoscan™)	150-773 & 0.9% Saline	150-771 **
In-111 Monoclonal Antibodies	150-773 & 0.9% Saline	150-771 **
In-111/Y-90 Zevalin™	0.9% Saline	150-772
I-131 Monoclonal Antibodies And Neutrospec™	0.9% Saline	150-771

* See Sigma-Aldrich product matrix for solvents.
** Note: A Well Plate is suggested to perform QC on these radiopharmaceuticals
Contact Fisher Scientific Corp. 800-766-7000 / www.fishersci.com / Item #14-245-71

Manuals

Models and Ordering

To order, call +45 32 50 66 10

Chromatography Strips

150-001	Strips, RED, 50/pkg?
150-005	Strips, BLACK, 50/pkg
150-025	Strips, YELLOW, 50/pkg
150-122	Strips, ORANGE, 50/pkg
150-125	Strips, LIGHT BLUE, 50/pkg
150-127	Strips, GREEN, 50/pkg
150-130	Strips, GOLD, 50/pkg
150-771	Strips, DARK GREEN, 50/pkg
150-772	Strips, BLUE, 50/pkg
150-951	Strips, LIME, 50/pkg
150-952	Strips, PEACH, 50/pkg
150-971	Strips, TEAL, 50/pkg
150-991	Strips, PINK, 50/pkg
150-782	Strips, ALUMINUM, 50/pkg

Chromatography Solvents

150-160	Solvent, 20% Sodium Chloride, 30 ml?
150-773	Solvent, DTPA, 5 ml
150-781	Solvent, Aluminum Standard, 5 ml, 10 µg/ml
150-783	Solvent, Aluminum Standard, 5 ml, 5 µg/ml

Related Items:

150-960	Developing Vials, 10 ml, 288/case (used for all Tec-Control testing)?
150-961	Developing Vials, 5 ml, 144/case (used for Sestamibi & Tetrofosmin)
066-533	Forceps, Curved, Locking, 9.5" l (24.1 cm)
066-535	Forceps, Straight, Locking, 9.5" l (24.1 cm)
066-536	Forceps, Curved, Non-Locking, 12.5" l (31.7 cm)

Tec-Control Solvent Vendor: Sigma-Aldrich Chemical Company 800-558-9160 / www.sigmaaldrich.com Note: Customers outside the US should visit Sigma-Aldrich web site to locate a regional office.
Solvent Description	Vendor Part #
Acetone HPLC Grade
Ethyl Acetate 99.5% ACS Reagent
Chloroform 99.8% ACS Reagent
Tetrahydrofuran 99+% ACS Reagent